Target intelligence / Profile preview

Mycobacterial Protein Synthesis Machinery

Molecular classification
Ribosome, Translation Factors, tRNAs, Aminoacyl-tRNA synthetases (AARS)
01

Overview

The mycobacterial protein synthesis machinery refers to the collection of molecular components and processes responsible for translating genetic information into proteins in mycobacteria, most notably *Mycobacterium tuberculosis*. This machinery is essential for cell survival and proliferation, making it a critical target for antibiotic development. It differs from other bacteria due to unique structural elements allowing survival under nutrient-limited or stressful conditions. These differences provide opportunities for developing antibiotics that specifically target mycobacteria without affecting human or other bacterial cells.

02

Mechanism of action

Inhibition of protein synthesis

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Biological functions

Protein synthesisTranslation of mRNARibosome assembly
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Disease associations

InfectionTuberculosis
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Safety considerations

Off-target effects on human cellsOff-target effects on commensal bacteriaAntibiotic resistance
06

Interacting drugs

Chloramphenicol

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