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Mycobacterial Respiratory Chain Enzymes
- Molecular classification
- Enzyme, Protein Complex
01
Overview
Mycobacterial respiratory chain enzymes are a set of membrane-bound protein complexes and associated electron carriers that drive oxidative phosphorylation in mycobacteria, including *Mycobacterium tuberculosis* (Mtb). These enzymes are essential for energy production, redox balance, and survival of the pathogen. The respiratory chain is highly branched and includes several key complexes: NADH dehydrogenase (Complex I), succinate dehydrogenase (Complex II), cytochrome bc1-aa3 supercomplex (Complex III-IV), cytochrome bd oxidase, and various quinones such as menaquinone. Nitric oxide (NO) produced by host immune cells can inhibit or damage components of the mycobacterial respiratory chain. Mtb has evolved mechanisms to evade or resist NO-mediated inhibition.
- Other names
- Mycobacterial Electron Transport ChainMtb Respiratory ChainMycobacterial Oxidative Phosphorylation System
02
Mechanism of action
Inhibition of electron transport chain complexes, disruption of ATP synthesis
03
Biological functions
Energy generationOxidative phosphorylationRedox balanceATP synthesis
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistanceOff-target effects on human mitochondrial respiratory chain
06
Interacting drugs
Bedaquiline
1 more in the full profile.
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