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Target intelligence / Profile preview
Mycobacterium avium Complex (MAC) Cell Wall Synthesis (MAC Cell Wall Synthesis)
- Target
- MAC Cell Wall Synthesis
- Molecular classification
- Pathway, Enzyme complex, Metabolic pathway
01
Overview
The Mycobacterium avium complex (MAC) cell wall is a complex and essential structure responsible for maintaining cell integrity, providing resistance to environmental stressors, and contributing to virulence. It is composed of peptidoglycan, arabinogalactan, mycolic acids, and serovar-specific glycopeptidolipids (ssGPLs). Inhibition of cell wall synthesis disrupts bacterial integrity, increases permeability, and enhances susceptibility to other antibiotics or host defenses. Key enzymes involved in the synthesis pathways, such as MurG, RodA, PonA1, and Crs acetyltransferase, are potential drug targets.
- Other names
- MAC cell wallMycobacterium avium complex cell wallMAC cell wall biosynthesis
02
Mechanism of action
Inhibition of cell wall biosynthesis enzymes, leading to cell wall disruption, increased permeability, and cell death.
03
Biological functions
Cell wall biosynthesisStructural integrityDrug resistanceVirulence
04
Disease associations
Mycobacterium avium complex infectionInfectionAntimicrobial resistance
05
Safety considerations
Drug resistanceOff-target effects on human cell wall synthesis (less likely)Potential for disruption of commensal microbial communities
06
Interacting drugs
Ethambutol
1 more in the full profile.
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