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Mycobacterium avium subspecies paratuberculosis Antigen (None)
- Target
- None
- Molecular classification
- Bacterial antigens, Proteins, Heat shock protein (GroES), Serine protease
01
Overview
Mycobacterium avium subspecies paratuberculosis (MAP) antigens are molecular components derived from MAP, the causative agent of Johne's disease in ruminants. These antigens, including proteins like GroES, 32-kDa secreted protein, and 34-kDa cell wall antigen/protease, are used in diagnostic assays (ELISA) to detect anti-MAP antibodies, aiding in veterinary surveillance. There is also concern about zoonotic transmission and a possible link to human diseases like Crohn’s.
02
Mechanism of action
N/A
03
Biological functions
Immune response inductionAntibody bindingT-cell activationFibronectin binding
04
Disease associations
Johne's diseasePotential association with Crohn's diseasePotential association with rheumatoid arthritis
05
Safety considerations
Potential for zoonotic transmission through contaminated foodHeat resistance of organism
06
Biomarkers
Anti-MAP antibodies (in serum/milk)
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