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Target intelligence / Profile preview
Mycobacterium bovis (attenuated) (BCG)
- Target
- BCG
- Molecular classification
- Bacterium, Live attenuated vaccine
01
Overview
Mycobacterium bovis is a slow-growing, aerobic, acid-fast bacterium whose attenuated form, primarily the Bacillus Calmette-Guérin (BCG) vaccine strain, is used globally to prevent tuberculosis and other mycobacterial infections. Attenuation was achieved through repeated subcultivation, resulting in the loss of the RD1 genomic region, reducing virulence while retaining immunogenicity. BCG works by stimulating the immune system to develop protective immunity against Mycobacterium tuberculosis. It is also used therapeutically for bladder cancer immunotherapy but has safety concerns such as risks of disseminated infection for the immunocompromised.
- Other names
- Bacillus Calmette-GuérinBCG vaccine strainAttenuated Mycobacterium bovis
02
Mechanism of action
Live attenuated bacterium that stimulates the immune system to develop protective immunity against Mycobacterium tuberculosis.
03
Biological functions
Immune stimulationInduction of cellular immunityProphylaxis against tuberculosis
04
Disease associations
Prevention of TuberculosisBladder cancer immunotherapy
05
Safety considerations
Risk of disseminated BCG infection in immunocompromised individualsLocal injection site reactionsRare complications such as osteitis or lymphadenitis
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