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Target intelligence / Profile preview
Mycobacterium protein tyrosine phosphatase B (None)
- Target
- None
- Molecular classification
- Enzyme, Protein tyrosine phosphatase
01
Overview
Mycobacterium protein tyrosine phosphatase B (mPTPB), also known as PtpB, is a secreted enzyme produced by *Mycobacterium tuberculosis* (Mtb). It is an essential virulence factor that modulates host signaling pathways to promote bacterial survival inside macrophages. It exhibits triple-specificity phosphatase activity and dephosphorylates tyrosine, serine, and threonine residues. mPTPB subverts innate immune responses, blocks ERK1/2 and p38 MAP kinase-mediated IL-6 production, and promotes host cell survival via Akt pathway activation. It is a validated drug target with inhibitors showing promise as anti-TB agents.
- Other names
- PtpBmPTPBRv0153c protein
02
Mechanism of action
Selective inhibition of mPTPB activity
03
Biological functions
Immune evasionModulation of host immunityPromotion of mycobacterial survivalDephosphorylation of host cell proteinsRegulation of host signaling pathways
04
Disease associations
Tuberculosis pathogenesisVirulence factor
05
Safety considerations
Potential for off-target effects (though no human homologs with identical function exist)Development of resistance
06
Interacting drugs
I-A09
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