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Mycobacterium tuberculosis Antigen

Molecular classification
Protein, Peptide, Enzyme (certain antigens), Cell Wall Component (certain antigens)
01

Overview

Mycobacterium tuberculosis antigens are molecular components—primarily proteins—expressed by the bacterium *Mycobacterium tuberculosis* (Mtb), the causative agent of tuberculosis (TB). These antigens are recognized by the host immune system and play a central role in both infection control and diagnostic testing. They serve as targets for immune recognition, particularly by T cells, and some have enzymatic or structural roles in bacterial physiology. These antigens are relevant for diagnostics and vaccine development.

Other names
Mtb AntigenTuberculosis Antigen
02

Biological functions

Immune recognitionT-cell activationB-cell activationMycolic acid transfer (Ag85 complex)Bacterial cell wall synthesis (Ag85 complex)
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Disease associations

TuberculosisInfectionLatent Tuberculosis Infection (LTBI)
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Safety considerations

Immune evasion mechanismsVariability of immune response depending on HLA typePotential for false-negative diagnostic results in immunocompromised individuals
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Biomarkers

IFN-γ (after antigen stimulation)IL-12(p40)IP-10

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