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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen(s)
- Molecular classification
- Bacterial protein, Glycolipid, Lipoprotein
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Overview
Mycobacterium tuberculosis antigens are molecular components—primarily proteins, but also lipids and carbohydrates—expressed by the bacterium M. tuberculosis, the causative agent of tuberculosis (TB). These antigens are recognized by the host immune system and play critical roles in both pathogenesis and immune response, making them important targets for diagnostics, vaccine development, and therapeutic interventions. Key examples include the Antigen 85 Complex (Ag85A, Ag85B, Ag85C), PE-PGRS family proteins, PTRP, MtrA, and Lipoarabinomannan (LAM).
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Biological functions
Cell wall synthesisCell wall maintenanceVirulence factorImmune response elicitation
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Disease associations
InfectionTuberculosis
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Safety considerations
Cross-reactivity with non-tuberculous mycobacteria in diagnostic assaysPotential for immune evasion by certain antigens
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Biomarkers
Active TB diagnosisLatent TB diagnosisPreclinical TB diagnosisTreatment response monitoring
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