Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen 85B (None)
- Target
- None
- Molecular classification
- Enzyme, Mycolyltransferase
01
Overview
The Ag85B protein is a major secreted antigen and mycolyltransferase enzyme produced by *Mycobacterium tuberculosis*. It is part of the antigen 85 (Ag85) complex and plays an essential role in the biosynthesis of the mycobacterial cell wall. Ag85B catalyzes transesterification reactions to synthesize trehalose monomycolate (TMM), trehalose dimycolate (TDM), and mycolated arabinogalactan. It is a prominent candidate for subunit vaccines against TB and considered an attractive drug target.
- Other names
- Ag85BFbpBDiacylglycerol acyltransferase/mycolyltransferase
02
Mechanism of action
Inhibition of mycolyltransferase activity, disruption of cell wall synthesis
03
Biological functions
Cell wall biosynthesisLipid metabolismImmune response
04
Disease associations
Infection
05
Safety considerations
Potential for immune-mediated inflammatory responsesNeed for specific inhibitors to avoid off-target effects
Beyond the preview
Go deeper on Mycobacterium tuberculosis Antigen 85B (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mycobacterium tuberculosis Antigen 85B (None).