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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen Ag85B
- Molecular classification
- Enzyme, Mycolyltransferase, Fibronectin-binding protein, Antigen
01
Overview
Antigen 85B (Ag85B) is a major secreted protein of Mycobacterium tuberculosis (Mtb). It functions as a diacylglycerol acyltransferase/mycolyltransferase, crucial for cell wall biosynthesis. Ag85B is highly immunogenic, inducing strong T-cell proliferation and IFN-γ secretion. It is a target for vaccine development and is used in diagnostic assays.
- Other names
- FbpBFibronectin binding protein BExtracellular alpha-antigenDiacylglycerol acyltransferase/mycolyltransferase 85BMycolyl transferase 85B
02
Mechanism of action
N/A
03
Biological functions
Cell wall biosynthesisImmune evasionFibronectin bindingT-cell activationIFN-gamma production
04
Disease associations
TuberculosisInfection
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