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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen Mtb39A (Mtb39A)
- Target
- Mtb39A
- Molecular classification
- PE/PPE protein family, Antigen
01
Overview
Mtb39A is a 39-kDa protein antigen of Mycobacterium tuberculosis. It belongs to the PE/PPE protein family and is conserved among M. tuberculosis and M. bovis BCG. It is an intracellular protein that elicits a strong T-cell response, making it a potential diagnostic and vaccine candidate. Recombinant Mtb39A is used in ELISA assays for TB diagnosis, and DNA immunization studies have shown protective effects in animal models. It is also a component of the M72/AS01E vaccine.
- Other names
- MTB39A proteinmtb39a gene product
02
Mechanism of action
N/A
03
Biological functions
T-cell activationImmune responseAntigen presentation
04
Disease associations
TuberculosisInfection
05
Biomarkers
Antibody detection for TB diagnosisT-cell response in PPD-positive individuals
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