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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen Rv1813 (Rv1813)
- Target
- Rv1813
- Molecular classification
- Antigen, Latency-associated protein
01
Overview
Rv1813 is a latency-associated antigen of *Mycobacterium tuberculosis* (Mtb), upregulated during the dormant phase of infection. It is a strong inducer of T cell responses and interferon-gamma (IFN-γ) secretion, making it a target for vaccine development. Rv1813 is included in experimental multistage subunit vaccines to provide protection against both primary infection and reactivation from latency. Its high epitope promiscuity ensures broad population coverage.
- Other names
- rv1813rv1813c
02
Mechanism of action
Not applicable; Rv1813 is a target for vaccine development, not a drug target itself. The mechanism involves stimulating T cell responses.
03
Biological functions
Immune responseT cell stimulationIFN-γ secretionDormancy maintenance (Mtb)
04
Disease associations
TuberculosisLatent Tuberculosis Infection
05
Safety considerations
Potential for excessive immune responseNeed for careful adjuvant selection to avoid adverse effects
06
Biomarkers
T cell response to Rv1813 as a marker of LTBIIFN-γ secretion in response to Rv1813 as a marker of cellular immunity
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