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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen Rv3619 (Rv3619)
- Target
- Rv3619
- Molecular classification
- Antigen, Protein
01
Overview
Rv3619 is a protein antigen from Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis. It is an immunodominant antigen known for inducing strong TNF responses during early infection. Rv3619 has been incorporated into multi-antigen fusion proteins, such as ID93, as a subunit vaccine candidate against TB.
- Other names
- Mtb Antigen Rv3619Rv3619 protein
02
Biological functions
Immune responseAntigen presentationTNF induction
03
Disease associations
InfectionTuberculosis
04
Safety considerations
Potential for off-target immune responsesRisk of immune enhancement of disease
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