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Target intelligence / Profile preview
Mycobacterium tuberculosis antigens
- Molecular classification
- Bacterial protein antigens, Bacterial lipid antigens, Bacterial glycan antigens
01
Overview
Mycobacterium tuberculosis antigens are molecular components—primarily proteins and lipids—expressed by the bacterium responsible for tuberculosis (TB). These antigens play crucial roles in host-pathogen interactions, immune recognition, diagnosis, vaccine development, and as potential drug targets. Key examples include the Antigen 85 Complex (Ag85A, Ag85B, Ag85C) involved in cell wall assembly, and the Dormancy Survival Regulon (DosR) Antigens expressed during latent infection.
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Biological functions
Cell wall synthesis/maintenanceImmune evasionHost-pathogen interactionStimulate T-cell responses
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Disease associations
InfectionTuberculosisLatent TB infection
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Biomarkers
Early detection of active or preclinical TBMonitoring treatment responseDifferentiation between latent infection versus active disease
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