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Target intelligence / Profile preview
Mycobacterium tuberculosis Cell Wall Synthesis Enzymes (Mtb Cell Wall Enzymes)
- Target
- Mtb Cell Wall Enzymes
- Molecular classification
- Enzyme
01
Overview
The cell wall of Mycobacterium tuberculosis (Mtb) is a complex, multilayered structure essential for bacterial survival, virulence, and resistance to antibiotics. The synthesis of this cell wall involves several key enzymes that are critical drug targets due to their essential roles in building and maintaining the unique architecture of the Mtb envelope. These enzymes participate in the biosynthesis of major cell wall components: peptidoglycan, arabinogalactan, and mycolic acids. Key enzymes include PonA1, PonA2, LdtB, DprE1, Culp6, and RmlA-RmlD. Targeting these enzymes is a major strategy for anti-tubercular drug development.
- Other names
- Mtb cell wall biosynthesis enzymesMycobacterial cell wall enzymesPeptidoglycan synthases (Mtb)Arabinogalactan biosynthetic enzymes (Mtb)Mycolic acid biosynthetic enzymes (Mtb)dTDP-L-rhamnose pathway enzymes (Mtb)PonA1PonA2LdtBDprE1Culp6RmlARmlBRmlCRmlD
02
Mechanism of action
Inhibition of cell wall biosynthesis
03
Biological functions
Cell wall synthesisPeptidoglycan biosynthesisArabinogalactan biosynthesisMycolic acid biosynthesisdTDP-L-rhamnose biosynthesis
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Drug resistanceOff-target effectsHepatotoxicity
06
Interacting drugs
Isoniazid
5 more in the full profile.
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