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Target intelligence / Profile preview
Mycobacterium tuberculosis ESAT6-CFP10 Fusion Protein (ESAT6-CFP10)
- Target
- ESAT6-CFP10
- Molecular classification
- Recombinant Antigen, Fusion Protein
01
Overview
The ESAT6-CFP10 fusion protein is a recombinant antigen derived from two key proteins secreted by *Mycobacterium tuberculosis*: ESAT-6 (Early Secreted Antigenic Target 6 kDa) and CFP-10 (Culture Filtrate Protein 10 kDa). These proteins are encoded within the RD1 region of the *M. tuberculosis* genome and are not present in most non-tuberculous mycobacteria or in BCG vaccine strains, making them highly specific markers for *M. tuberculosis* infection. It is primarily used as a diagnostic reagent in skin tests and immunoassays to detect TB infection.
02
Mechanism of action
Stimulates T-cell mediated immune responses; induces IFN-gamma production upon recognition by sensitized T-cells.
03
Biological functions
Stimulates cell-mediated immunityInduces IFN-gamma productionModulates host-pathogen interactionsInhibits autophagosome formation in macrophages
04
Disease associations
TuberculosisInfection
05
Biomarkers
Detection of latent or active TB infectionIFN-gamma release from T-cells
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