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Mycolic acid biosynthesis enzyme DprE1
- Molecular classification
- Enzyme, Flavoenzyme, Epimerase
01
Overview
DprE1 is a flavoenzyme essential for the biosynthesis of decaprenylphosphoryl-D-arabinose (DPA), a crucial precursor for arabinogalactan and lipoarabinomannan synthesis in mycobacteria, including *Mycobacterium tuberculosis*. As DPA is necessary for cell wall integrity, DprE1 is a validated drug target, and its inhibition leads to bacterial death.
- Other names
- decaprenylphosphoryl-β-D-ribose 2′-epimerase subunit 1DprE1Rv3790 product (*M. tuberculosis*)Decaprenylphosphoryl-D-ribose 2-epimerase
02
Mechanism of action
Inhibition of decaprenylphosphoryl-β-D-ribose 2′-epimerase activity, leading to disruption of cell wall synthesis
03
Biological functions
Cell wall biosynthesisArabinogalactan synthesisLipoarabinomannan synthesisEpimerization
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Potential for off-target effects due to flavoenzyme natureDevelopment of resistance
06
Interacting drugs
Benzothiazinones
1 more in the full profile.
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