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Mycolic Acid Synthesis Pathway (MAS Pathway)
- Target
- MAS Pathway
- Molecular classification
- Metabolic Pathway, Enzyme Cascade
01
Overview
Mycolic acid synthesis refers to the biosynthetic pathway responsible for producing mycolic acids—very long-chain, branched fatty acids that are essential components of the cell wall in Mycobacterium species, including *Mycobacterium tuberculosis*. This pathway involves several key enzymes including FAS-I, FAS-II, Acc, FadD32, Pks13, and CmrA. Inhibiting this pathway is a validated therapeutic strategy for tuberculosis.
- Other names
- Mycolic acid biosynthesisMycobacterial cell wall synthesis (mycolic acid component)
02
Mechanism of action
Inhibition of enzymes involved in mycolic acid synthesis, such as FAS-I, FAS-II, Acc, FadD32, Pks13, or CmrA
03
Biological functions
Lipid biosynthesisCell wall synthesisBacterial survivalVirulence
04
Disease associations
InfectionTuberculosisMycobacterial infections
05
Safety considerations
Drug resistance development through mutationsProdrug activation issues affecting drug efficacyPotential for off-target effects of inhibitors
06
Interacting drugs
Isoniazid (INH)
4 more in the full profile.
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