Mycoplasma hyopneumoniae antigens (M. hyo antigens)

Mycoplasma hyopneumoniae antigens are a diverse set of surface-exposed proteins and lipoproteins that facilitate the colonization and pathogenesis of Mycoplasma hyopneumoniae in swine. The most prominent among these is the P97 adhesin, which mediates the binding of the bacteria to the ciliated respiratory epithelium of the host (Source: PubMed, PMID: 10430030). Other significant antigens include lipoproteins such as P46 and P65, which are involved in immune modulation and nutrient acquisition (Source: UniProt). In the pharmaceutical industry, these antigens serve as the primary components of veterinary vaccines, such as Ingelvac MycoFLEX and RespiSure-ONE, designed to elicit protective humoral and cellular immune responses (Source: Merck Veterinary Manual). While these vaccines are effective at reducing the severity of lung lesions and improving growth rates in infected herds, they typically do not provide sterile immunity, meaning the bacteria can still colonize the host. Consequently, these antigens remain a focal point for the development of next-generation recombinant and subunit vaccines aimed at achieving broader protection and pathogen eradication.

Other names

Mycoplasma hyopneumoniae surface proteinsM. hyo antigensP97 adhesin complexMycoplasma hyopneumoniae lipoproteinsMhp1Mhp2

Induction of active immunity through the presentation of bacterial surface proteins to the host immune system, leading to the production of neutralizing antibodies and T-cell activation to prevent bacterial adherence.