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Target intelligence / Profile preview
Myelin-associated Glycoprotein (MAG)
- Target
- MAG
- Molecular classification
- Type I transmembrane protein, Glycoprotein, Adhesion molecule
01
Overview
Myelin-associated glycoprotein (MAG), also known as Siglec-4, is a type I transmembrane glycoprotein predominantly found in the periaxonal membranes of Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). MAG plays a crucial role in glial-axonal interactions, contributing to both the maintenance and stability of myelinated axons. It also inhibits neurite outgrowth after CNS injury. Clinically, autoantibodies against MAG are associated with certain forms of peripheral neuropathy.
- Other names
- Siglec-4
02
Mechanism of action
Modulation of MAG interactions via antibodies or other molecules
03
Biological functions
Axon-glia adhesionMaintains myelinated axonsInhibits neurite growthRegulation of cytoskeletal organizationEnhancing long-term stability at the node of Ranvier
04
Disease associations
Peripheral neuropathyMultiple sclerosisDemyelinating diseases
05
Safety considerations
Inhibition of nerve regeneration following CNS injuryPotential for off-target effects when targeting MAG
06
Biomarkers
Autoantibodies against MAG
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