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Myelin-Based Autoantigen (N/A)

Target: N/A
Molecular classification: Protein, Glycoprotein, Autoantigen

Overview

Myelin-based autoantigens are components of the myelin sheath in the central nervous system (CNS) that can become targets of autoimmune responses, particularly in demyelinating diseases such as multiple sclerosis (MS). The most studied myelin-based autoantigens include Myelin Basic Protein (MBP) and Myelin Oligodendrocyte Glycoprotein (MOG). Autoimmunity against these antigens underlies several neuroimmunological diseases.

Mechanism of action

N/A

Biological functions

Myelin Sheath FormationImmune Response ElicitationHomophilic Adhesion

Disease associations

Multiple SclerosisNeuromyelitis Optica Spectrum DisordersExperimental Autoimmune Encephalomyelitis (EAE)

Safety considerations

Autoimmune reactionsDemyelination

Biomarkers

Anti-MBP antibodiesAnti-MOG antibodies

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