Target intelligence / Profile preview

Myelin Basic Protein

Molecular classification: Intrinsically Disordered Protein, Structural Protein

Overview

Myelin basic protein (MBP) is a highly abundant, multifunctional protein that plays a central role in the structure and function of myelin sheaths in the nervous system. It is essential for maintaining the correct structure of myelin by mediating adhesion between cytosolic surfaces of compacted myelin layers. MBP also interacts with actin, tubulin, Ca²⁺/calmodulin complexes, clathrin, and SH3-domain proteins, and can be found in immune-related organs. Altered post-translational modification patterns of MBP, especially increased citrullination, are associated with demyelinating diseases such as multiple sclerosis (MS).

Biological functions

Myelin compaction and stabilizationSignal transductionCytoskeletal interactionActin bindingTubulin binding

Disease associations

Multiple SclerosisAlzheimer's Disease (potential)

Safety considerations

Autoantigen implicated in MS pathogenesis

Biomarkers

Increased T-cell reactivity against MBP (MS)Elevated levels of deiminated/citrullinated MBP (MS)

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