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Target intelligence / Profile preview
Myelin expression factor 2 (MYEF2)
- Target
- MYEF2
- Molecular classification
- Transcription factor, RNA-binding protein
01
Overview
Myelin expression factor 2 (MYEF2) is a transcriptional repressor protein primarily located in the nucleus, encoded by the MYEF2 gene on human chromosome 15. It represses the transcription of the myelin basic protein (MBP) gene by binding to the MB1 element of the MBP promoter, playing a role in brain development and neuronal differentiation. MYEF2 also has RNA binding activity and is involved in myotube differentiation. It is overexpressed in hepatocellular carcinoma and other cancers, promoting cell migration and invasion, and is emerging as a biomarker associated with tumor progression and prognosis, especially in liver cancer.
- Other names
- MYEF2KIAA1341MEF-2MyEF-2FLJ11213HsT18564MST156MSTP156myEF-2myelin gene expression factor 2
02
Biological functions
Transcriptional repressionRNA bindingmyotube differentiationneuron differentiationinhibition of myelin basic protein (MBP) gene transcriptionregulation of cell migration and invasion
03
Disease associations
Hepatocellular carcinomalung adenocarcinomaschwannomaoculocutaneous albinism (type VI)lung non-small cell carcinomapotentially other malignant tumors
04
Biomarkers
Potential prognostic biomarker for hepatocellular carcinoma (high MYEF2 expression associated with poor patient survival)
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