Myelin integrity pathways

"Myelin integrity pathways" refers to the constellation of cellular signaling networks and molecular mechanisms that regulate the formation, maintenance, and repair of the myelin sheath in the central and peripheral nervous systems. These pathways involve coordinated activities of various cell types—including oligodendrocytes, microglia, and astrocytes—and include intracellular signaling systems such as Wnt/β-catenin, PI3K/AKT/mTOR, and ERK/MAPK.[3][4] Maintaining myelin integrity is essential for rapid electrical conduction in axons, protection from neurotoxic environments, and supporting axonal health and survival.[1][2][5][6][7] Disruption of these pathways contributes to demyelinating diseases such as multiple sclerosis and other neurodegenerative disorders, but "myelin integrity pathways" is not itself a druggable molecular target; rather, individual protein components or receptors within these pathways (e.g., TGFβR1 in microglia, PLP1, CNPase, Myrf) are true molecular targets for therapeutic intervention.[3][4][5] In summary, "myelin integrity pathways" is a conceptual term that includes multiple molecular targets rather than naming a discrete, canonical target molecule or receptor.

Other names

Myelin maintenance pathwayspathways regulating myelin integritymyelin stability pathways