Myelin oligodendrocyte glycoprotein-reactive autoreactive effector memory T cell (null)

Myelin oligodendrocyte glycoprotein-reactive autoreactive effector and memory CD4+ and/or CD8+ T cells are populations of T lymphocytes that recognize antigens derived from myelin oligodendrocyte glycoprotein (MOG), a protein found on the outer surface of central nervous system myelin[2][3][6]. These T cells escape central and peripheral tolerance, become activated, and contribute to demyelination by attacking CNS myelin, either directly (by cytotoxicity or cytokine secretion) or indirectly by promoting recruitment of other inflammatory cells and facilitating entry of antibodies and immune mediators[2][4]. They are central to animal models of experimental autoimmune encephalomyelitis and play a pathogenic role in multiple human demyelinating diseases including MS and MOGAD, with CD4+ T cells generally having a dominant role but CD8+ T cells also being involved[1][2][6].

Other names

MOG-reactive T cellsMOG-specific effector memory CD4+ and/or CD8+ T cellsautoimmune T cells targeting MOG

Suppression of T cell proliferation or function; Depletion of immune cells; Modulation of antibody production