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Myelin peptide-specific T cell
- Molecular classification
- T lymphocyte, CD4+ T cell, CD8+ T cell
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Overview
Myelin peptide-specific T cells are a subset of T lymphocytes that recognize and respond to peptides derived from myelin proteins, such as myelin basic protein (MBP) and proteolipid protein (PLP), which are key components of the myelin sheath in the central nervous system. These cells play a central role in autoimmune demyelinating diseases, most notably multiple sclerosis (MS), where they contribute to immune-mediated damage of myelin.
02
Mechanism of action
T cell depletion; modulation of T cell function
03
Biological functions
Immune responseAntigen recognitionCytokine productionT cell activation
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Disease associations
AutoimmunityDemyelinationNeuroinflammationMultiple sclerosis
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Safety considerations
ImmunosuppressionIncreased risk of infectionExacerbation of autoimmunity
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Interacting drugs
Anti-CD20 monoclonal antibodies
07
Biomarkers
Frequency of myelin-specific T cellsActivation state of myelin-specific T cellsCytokine profile (IFN-γ, IL-17, GM-CSF, IL-10)Expression of activation markers (e.g., CD20)
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