Target intelligence / Profile preview

Myelin protein zero-like protein 1 (MPZL1)

Target: MPZL1
Molecular classification: Immunoglobulin superfamily, Cell surface receptor, Structural molecule, Transmembrane protein

Overview

Myelin protein zero-like protein 1 (MPZL1) is a cell surface receptor belonging to the immunoglobulin superfamily and is structurally related to myelin protein zero. It functions as an adhesion molecule and is implicated in cell signaling processes, especially those involving cell migration and integrin-mediated motility. MPZL1 serves as a receptor for concanavalin A and recruits phosphatases like PTPN11/SHP-2, impacting downstream signaling cascades. It exists as a homodimer, with dimerization facilitating its function in cell adhesion and signal transmission. MPZL1 is upregulated in several cancers, including hepatocellular carcinoma, and mutations are associated with Charcot-Marie-Tooth disease, indicating roles in tumor migration and neurodegenerative disorders[1][2][3][5].

Other names: MPZL1PZRMPZL1bPZR1bPZRaPZRbProtein zero-relatedFLJ21047UNQ849/PRO1787immunoglobulin family transmembrane proteinprotein zero related

Mechanism of action

Drugs modulating signal transduction through cell surface receptor pathways (specific drugs not identified)

Biological functions

Signal transductionCell surface receptor signalingCell-cell signalingRegulation of integrin-mediated cell motilityCell adhesion

Disease associations

Cancer (notably hepatocellular carcinoma)Charcot-Marie-Tooth disease type 2ICharcot-Marie-Tooth disease type 1

Safety considerations

No specific safety concerns or therapeutic challenges have been directly reported; safety would depend on pathway modulation and tissue distribution[2][5].

Biomarkers

MPZL1 upregulation in hepatocellular carcinoma cells is associated with increased migration, indicating possible use as a biomarker for tumor invasiveness[1][2].

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