Myelin-specific Autoreactive T Cell (N/A)

Myelin-specific autoreactive T cells are immune cells that recognize and respond to antigens derived from myelin, the insulating sheath surrounding nerve fibers in the central nervous system (CNS). These T cells play a central role in autoimmune demyelinating diseases such as multiple sclerosis (MS), where they mediate immune attacks against myelin, leading to neuroinflammation and tissue damage. Targeting these autoreactive populations is a key strategy for treating autoimmune demyelinating diseases.

Other names

Myelin-reactive T cellAutoreactive T cell (myelin-specific)Myelin-specific CD4+ T cellMyelin-specific CD8+ T cellMBP-specific T cellPLP-specific T cellMAG-specific T cellMOG-specific T cell

Modulation of T cell activation, cytokine production, and trafficking. Induction of tolerance or regulatory T cell responses. Depletion of specific T cell subsets.