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Target intelligence / Profile preview
Myelin transcription factor 1 kinase (Myt1)
- Target
- Myt1
- Molecular classification
- Transcription factor, Serine/threonine-protein kinase, DNA-binding protein, Enzyme
01
Overview
Myt1 is a neural-specific protein with dual functions as a transcription factor and a kinase. It regulates myelin gene expression and inhibits Cdk1 to control cell cycle progression. Its roles in neurodevelopment and cell cycle make it a potential therapeutic target for neurodevelopmental disorders, demyelinating diseases, and cancer.
- Other names
- MYT1Myt1 kinase
02
Mechanism of action
Phosphorylation and inhibition of Cdk1
03
Biological functions
Transcriptional regulationCell cycle controlKinase activityCell proliferationCell differentiationOrganelle reassembly
04
Disease associations
Neurodevelopmental disordersDemyelinating diseasesCancer
05
Safety considerations
Potential impact on normal cell cycle regulation if targeted systemicallyOff-target effects due to kinase activity
06
Interacting drugs
Wee family kinase inhibitors (indirectly, contributes to resistance)
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