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Target intelligence / Profile preview
Myeloid Cell Leukemia Sequence 1 (Mcl-1)
- Target
- Mcl-1
- Molecular classification
- BCL2 family protein, Anti-apoptotic protein
01
Overview
Myeloid cell leukemia sequence 1 (Mcl-1) is a member of the BCL2 family, acting as an anti-apoptotic regulator that promotes cell survival. Overexpression is frequently observed in cancers contributing to tumor progression and therapy resistance. Targeting Mcl-1 can sensitize cancer cells to apoptotic stimuli, but challenges remain due to its structural features and essential physiological roles.
- Other names
- MCL1Bcl-2-related proteinMCL1L
02
Mechanism of action
Small molecule inhibitors targeting the BH3-binding groove to induce apoptosis.
03
Biological functions
Anti-apoptosisCell survivalRegulation of apoptosisMitochondrial homeostasisEnergy production
04
Disease associations
CancerTherapy resistanceTumor progression
05
Safety considerations
Essential physiological roles may lead to toxicityStructural features pose challenges for inhibitor design
06
Interacting drugs
Mcl-1 inhibitors
2 more in the full profile.
07
Biomarkers
Mcl-1 expression levels in tumors
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