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Target intelligence / Profile preview
Myeloid Cell Surface Protein
- Molecular classification
- Receptor, Integrin, C-type Lectin, Other
01
Overview
Myeloid cell surface proteins are a diverse group of proteins expressed on the surface of cells derived from the myeloid lineage (monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes, and erythrocytes). These proteins serve as markers for identifying myeloid cell subtypes and play critical roles in immune response regulation, cell signaling, migration, and interaction with other immune cells. They are important in sensing infection or tissue injury, regulating recruitment and differentiation, mediating phagocytosis, and modulating inflammation. These proteins are used as diagnostic/prognostic biomarkers in hematological malignancies and as therapeutic targets.
- Other names
- Myeloid surface markerMyeloid cell marker
02
Mechanism of action
Varies depending on the specific protein. Examples include: Antibody-mediated cytotoxicity, receptor blockade, signal modulation.
03
Biological functions
Recognition of pathogens and tissue damageInitiation and regulation of inflammatory responsesPhagocytosisAntigen presentationRegulation of innate and adaptive immunityCell adhesionCell migrationCell signaling
04
Disease associations
CancerInflammationInfectionAutoimmune diseasesHematological malignancies
05
Safety considerations
Off-target effects due to broad expression of some markersImmunosuppressionCytokine release syndromePotential for affecting normal myeloid cell function
06
Interacting drugs
Antibody-drug conjugates (targeting CD33)
1 more in the full profile.
07
Biomarkers
CD33 (AML diagnosis/prognosis)CD11b/CD18 (Neutrophil/macrophage activation)F4/80 (Macrophage marker in mice)Gr-1 (Neutrophil marker in mice)MDL-1 (Myeloid cell activation)
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