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Target intelligence / Profile preview
Myeloid-Derived Suppressor Cell (MDSC)
- Target
- MDSC
- Molecular classification
- Immune cell, Myeloid cell, Heterogeneous cell population
01
Overview
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells characterized by their potent immunosuppressive activity. They suppress T cell activity, modulate innate immunity, and contribute to tumor progression by inhibiting antitumor immunity, promoting angiogenesis, facilitating metastasis, and contributing to drug resistance. MDSC-mediated immunosuppression involves depletion of nutrients, production of reactive oxygen species (ROS) and nitric oxide (NO), and secretion of immunosuppressive cytokines.
- Other names
- Myeloid suppressor cellsMDSCsMonocytic-MDSCM-MDSCPolymorphonuclear-MDSCGranulocytic-MDSCG-MDSC
02
Mechanism of action
Inhibition of T cell activation via nutrient depletion, ROS/NO production, and immunosuppressive cytokine secretion; Indoleamine 2,3-dioxygenase (IDO) induction
03
Biological functions
ImmunosuppressionT cell inhibitionRegulation of innate immunityAngiogenesis promotionMetastasis promotionModulation of immune cell activity
04
Disease associations
Cancer progressionTumor microenvironment modulationChronic infectionsAutoimmune diseasesInflammation
05
Safety considerations
Potential for off-target effects due to targeting molecules also present on other cell types.Risk of exacerbating infections by enhancing immunosuppression.Possible disruption of normal immune homeostasis.Development of resistance to MDSC-targeting therapies.
06
Biomarkers
CD11bCD33CD14HLA-DRCD15Gr-1Ly6GLy6C
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