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Myeloid-Derived Suppressor Cell Expressing NKG2D Ligand (None)
- Target
- None
- Molecular classification
- Myeloid cell, NKG2D Ligand
01
Overview
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells known for their potent immunosuppressive activity. The expression of NKG2D ligands (NKG2DLs) on MDSCs makes them targets for NK cells and cytotoxic T lymphocytes (CTLs) via the NKG2D receptor. This interaction can lead to both immune activation (killing of MDSCs) and immune suppression (exhaustion of effector cells), depending on the context and the tumor's manipulation of the pathway. Therefore, modulating the NKG2D-NKG2DL axis on MDSCs is being explored as a therapeutic strategy in cancer immunotherapy.
- Other names
- NKG2D Ligand expressing MDSCMDSC-NKG2DL
02
Mechanism of action
Modulation of NKG2D-NKG2D ligand interaction to enhance or suppress immune responses.
03
Biological functions
Immune suppressionAntigen presentationT cell regulationNK cell regulation
04
Disease associations
CancerChronic inflammationAutoimmune diseaseInfection
05
Safety considerations
Potential for immune-related adverse eventsRisk of exacerbating autoimmune diseasesOff-target effects on other NKG2D-expressing cells
06
Biomarkers
MDSC population levelsNKG2D ligand expression levels on MDSCsNK cell activityT cell activity
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