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Target intelligence / Profile preview
Myeloid Zinc Finger Protein 1 (MZF1)
- Target
- MZF1
- Molecular classification
- Transcription factor, SCAN-Zinc Finger Proteins
01
Overview
Myeloid zinc finger protein 1 (MZF1) is a sequence-specific DNA-binding transcription factor. It regulates genes involved in hematopoietic differentiation, cell proliferation, apoptosis, migration, invasion, and oncogenesis. MZF1 functions both as a transactivator and transrepressor. Aberrant expression contributes to leukemogenesis and other hematologic malignancies and solid tumors. Its dual role in cancer depends on cellular context and interacting partners. Phosphorylation and SUMOylation modulate its activity.
- Other names
- MZF-1MZF1BZFP98ZNF42ZSCAN6
02
Mechanism of action
Sequence-specific DNA binding via zinc finger domains; transcriptional regulation (transactivation or transrepression)
03
Biological functions
Transcriptional regulationHematopoiesisCell proliferationApoptosisCell migrationCell invasion
04
Disease associations
LeukemiaMyelodysplasiaSolid tumorsCancer
05
Safety considerations
Dual role in cancer (can promote proliferation or induce apoptosis depending on context)Involvement in EMT, migration, and invasion pathways
06
Biomarkers
MZF1 expression levels in certain cancers
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