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Target intelligence / Profile preview
Myeloma-Associated Antigens (MAA)
- Target
- MAA
- Molecular classification
- Protein, Peptide, Tumor-associated antigen, Cancer-testis antigen, Cell surface antigen
01
Overview
Myeloma-associated antigens are a group of proteins or peptides specifically or preferentially expressed by malignant plasma cells in multiple myeloma (MM). They can be presented on the surface of myeloma cells via HLA molecules and recognized by T-cells, making them attractive targets for immunotherapy. These antigens include cancer-testis antigens and lineage-restricted markers like BCMA. Therapeutic strategies include vaccines, T-cell therapies, and antibody-based treatments. Their expression profile helps minimize off-tumor toxicity while maximizing anti-myeloma immune responses.
- Other names
- Multiple Myeloma AntigensMM Antigens
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), T-cell redirection, direct cell killing
03
Biological functions
Immune recognitionCell survivalApoptosis regulationT-cell activationTumor growth
04
Disease associations
Multiple MyelomaCancerImmune evasion
05
Safety considerations
Off-tumor toxicityCytokine release syndrome (CRS)NeurotoxicityOn-target, off-tumor effects
06
Interacting drugs
Daratumumab
5 more in the full profile.
07
Biomarkers
MAGE-A3/A6 expressionMAGE-C1/CT7 expressionBCMA (CD269/TNFRSF17) expressionHLA-presented peptide detection
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