Target intelligence / Profile preview

Myeloperoxidase (MPO)

Target: MPO
Molecular classification: Enzyme, Peroxidase, Heme protein

Overview

Myeloperoxidase (MPO) is a heme-containing peroxidase enzyme primarily found in neutrophils. It plays a key role in the innate immune response by generating potent oxidants like hypochlorous acid to kill pathogens. However, excessive or misdirected MPO activity contributes to inflammatory diseases and cardiovascular disease by causing oxidative damage. MPO activity can also be modulated by plasma proteins.

Mechanism of action

Inhibition of MPO activity can reduce oxidative stress and inflammation.

Biological functions

Host defenseMicrobial killingOxidation of halidesGeneration of reactive oxygen speciesFormation of neutrophil extracellular traps

Disease associations

InflammationCardiovascular diseaseAtherosclerosisInfection

Safety considerations

Excessive inhibition of MPO could impair host defense against infection.MPO release can cause tissue damage via oxidative stress.

Biomarkers

MPO levels are a biomarker for cardiovascular risk and inflammation.

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