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Target intelligence / Profile preview
Myeloperoxidase propeptide peptide:HLA-A*02:01 (MPO132-140:HLA-A*02:01)
- Target
- MPO132-140:HLA-A*02:01
- Molecular classification
- Other (peptide:MHC class I complex)
01
Overview
This is a specific peptide derived from the propeptide region of myeloperoxidase (MPO), particularly the MPO132-140 epitope, presented in complex with the human leukocyte antigen (HLA) class I molecule HLA-A*02:01 and beta-2-microglobulin (B2M). It functions as a myeloid leukemia-restricted antigen recognized by T-cell receptors (TCRs), enabling TCR-T cell therapies to target and kill leukemia cells while showing restricted expression on normal hematopoietic cells like promyelocytes. Structural studies confirm stable binding of such non-canonical peptides to HLA-A*02:01, supporting T-cell immunity in cancer contexts.
- Other names
- MPO propeptide:HLA-A*02:01
02
Biological functions
Antigen presentationImmune response
03
Disease associations
Cancer (myeloid leukemia)
04
Safety considerations
Potential on-target toxicity to normal myeloid cells (e.g., promyelocytes)
05
Biomarkers
Myeloid leukemia-restricted antigen
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