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Target intelligence / Profile preview
MYO18B antisense RNA 1 (MYO18B-AS1)
- Target
- MYO18B-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)[5]
01
Overview
MYO18B antisense RNA 1 (MYO18B-AS1) is a human long non-coding RNA (lncRNA) gene located on chromosome 22 (22q) that is transcribed antisense to the protein-coding MYO18B gene[1][3][5]. As with many lncRNAs, the detailed function is not well established, but it may be involved in gene or chromatin regulation and has associations with rare congenital syndromes including Klippel-Feil syndrome linked to myopathies and facial dysmorphism[5]. There is currently no evidence to support MYO18B-AS1 as a classic therapeutic target, receptor, or enzyme, nor are there known drug interactions or established biomarker or safety data for clinical targeting.
- Other names
- MYO18B-AS1MYO18B antisense RNA 1HGNC:40831NCBI Gene: 105372963Ensembl: ENSG00000231933
02
Biological functions
Likely gene regulation via antisense interactionOther (lncRNA functions are often poorly characterized)[5]
03
Disease associations
Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome[5]Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism[5]
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