Myocardial energy metabolism modulation

Myocardial energy metabolism modulation is a therapeutic approach that aims to optimize the heart's energy utilization by altering the selection and processing of substrates (fatty acids, glucose, ketone bodies, lactate) for ATP production[4][5]. The myocardium relies on a network of transporters, metabolic enzymes, and mitochondrial processes to maintain adequate energy supply during health and disease[1][3]. In conditions such as heart failure or diabetes, myocardial substrate preference and energy efficiency are disrupted, contributing to impaired contractility and disease progression[2][3]. Drugs targeting these pathways seek to restore metabolic balance, improve cardiac energetics, and minimize stress-induced injury. This entry describes a therapeutic strategy/process, not a single molecular target, and thus cannot be directly mapped to a molecule/receptor database structure.

Other names

Metabolic modulationcardiac metabolic modulationmyocardial metabolic modulation

Shift myocardial substrate use from fatty acids to glucose (improves efficiency and reduces oxygen consumption)[4][5]; Inhibition of fatty acid oxidation (e.g., trimetazidine, perhexiline); Enhancement of glucose oxidation; Modulation of key mitochondrial enzymes (pyruvate dehydrogenase kinase inhibition); Modulation of substrate transporters (GLUT, CD36, CPT)[1][2][5]