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Myocardial Fatty Acid Metabolism (Myocardial FAO)
- Target
- Myocardial FAO
- Molecular classification
- Metabolic Pathway
01
Overview
Myocardial fatty acid metabolism refers to the process by which free fatty acids (FFAs) are taken up by cardiac cells and undergo beta-oxidation within mitochondria to generate energy required for the heart’s continuous contractile activity. In a healthy adult heart, 60–90% of ATP production is derived from the oxidation of long-chain fatty acids, making them the predominant energy substrate compared to carbohydrates, ketone bodies, and amino acids. Alterations in myocardial fatty acid metabolism are implicated in various forms of heart disease. Modulating myocardial FAO has been explored therapeutically.
- Other names
- Cardiac Fatty Acid OxidationMyocardial Lipid Metabolism
02
Mechanism of action
Modulation of fatty acid uptake, transport, and oxidation
03
Biological functions
Energy productionATP synthesisCardiac muscle contractionSubstrate utilization
04
Disease associations
Heart failureIschemiaObesity-induced cardiac dysfunctionDiabetes-induced cardiac dysfunctionLipotoxicity
05
Safety considerations
Potential for adverse effects on overall cardiac functionMixed clinical trial results
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