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Myocardial Metabolism
- Molecular classification
- Metabolic Pathway, Biochemical Process
01
Overview
Myocardial metabolism encompasses the biochemical pathways by which the heart muscle generates and utilizes energy, primarily ATP, to sustain contractile activity. It involves fatty acid oxidation, glucose metabolism, and the phosphocreatine system, all tightly regulated and influenced by factors such as PPARs. Pathophysiological changes in heart failure and ischemia alter substrate preference, often impairing energy production. Targeting myocardial metabolic pathways presents therapeutic opportunities for treating cardiac diseases.
- Other names
- Cardiac MetabolismHeart Muscle MetabolismMyocardial Energy Metabolism
02
Mechanism of action
Modulation of fatty acid oxidation and/or glucose metabolism
03
Biological functions
Energy ProductionATP SynthesisMuscle ContractionIon Homeostasis
04
Disease associations
Heart FailureIschemiaCardiomyopathyDiabetic CardiomyopathyMyocardial Infarction
05
Safety considerations
Off-target metabolic effectsSubstrate preference shiftsDrug-induced metabolic stressMetabolic inflexibilityExacerbation of underlying metabolic disorders
06
Interacting drugs
Trimetazidine
2 more in the full profile.
07
Biomarkers
Lactate LevelsKetone Body LevelsBCAA levelsFatty acid oxidation rateGlucose uptake rate
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