Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Myocardin-Related Transcription Factor B (MRTF-B)
- Target
- MRTF-B
- Molecular classification
- Transcription factor, Myocardin family
01
Overview
Myocardin-related transcription factor B (MRTF-B) is a member of the myocardin family of transcriptional coactivators. It acts as a powerful coactivator for serum response factor (SRF), a ubiquitously expressed transcription factor essential for cardiac and smooth muscle gene regulation. MRTF-B is broadly expressed and plays key roles in cardiovascular morphogenesis, neuronal development, and cytoskeletal organization. It is regulated by actin dynamics and Rho signaling, and its knockout leads to severe cardiovascular defects and embryonic lethality.
- Other names
- MKL2MAL16
02
Biological functions
CoactivationSignal integrationTranscriptional regulationCell differentiationCytoskeleton remodelingGene expression regulation
03
Disease associations
Cardiovascular diseaseDevelopmental disorders
04
Safety considerations
Potential developmental toxicityComplex role in multiple tissues
Beyond the preview
Go deeper on Myocardin-Related Transcription Factor B (MRTF-B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Myocardin-Related Transcription Factor B (MRTF-B).