Target intelligence / Profile preview

Myoglobin (MB)

Target: MB
Molecular classification: Protein, Oxygen-binding protein

Overview

Myoglobin is a small, globular protein found primarily in the striated (skeletal and cardiac) muscles of vertebrates. It serves as an oxygen-storage unit, providing oxygen to working muscles and facilitating oxygen transport within muscle cells. Muscle injury can cause release into blood; elevated levels serve as an early biomarker for acute muscle damage or rhabdomyolysis. Excessive circulating myoglobin can be nephrotoxic if not cleared efficiently by kidneys.

Biological functions

Oxygen storageOxygen diffusionReactive oxygen species scavenger

Disease associations

Muscle damage biomarkerNephrotoxicity (in rhabdomyolysis)

Safety considerations

Nephrotoxicity (due to excessive circulating myoglobin)

Biomarkers

Acute muscle damageMyocardial infarctionRhabdomyolysis

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