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Myoinositol
- Molecular classification
- Cyclic carbohydrate, Cyclohexanehexol, Inositol
01
Overview
Myoinositol is a naturally occurring cyclic carbohydrate crucial for cell signaling, lipid metabolism, and insulin sensitivity. It serves as a precursor for phosphatidylinositol and phosphoinositides. While not a direct drug target, it is supplemented to address conditions like PCOS, metabolic syndrome, and insulin resistance. It plays a role in FSH signaling and potentially mood regulation.
- Other names
- Inositol, myo-meso-Inositoli-InositolDambosePhaseomanniteVitamin B8 (historical)
02
Mechanism of action
Myoinositol itself is not directly targeted by drugs. It acts as a supplement to influence metabolic and signaling pathways.
03
Biological functions
Precursor for phosphatidylinositol synthesisPrecursor for phosphoinositide synthesisSecond messenger system componentInsulin sensitivity modulationLipid metabolism regulationFSH signaling supportOvarian follicle maturation supportMood regulation (serotonin modulation)
04
Disease associations
Polycystic Ovary Syndrome (PCOS)Metabolic SyndromeInsulin ResistanceGestational DiabetesMood Disorders (potential)Autism Spectrum Disorders (potential)
05
Safety considerations
Generally safe at typical dosesHigh doses may cause mild gastrointestinal discomfortPCOS patient resistance (approx. 30%) due to absorption issues
06
Biomarkers
Myoinositol:D-chiro-inositol plasma ratio (for PCOS treatment optimization)
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