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Target intelligence / Profile preview
Myoma-Associated Antigen-Expressing Cell (N/A)
- Target
- N/A
- Molecular classification
- Cell Type
01
Overview
Myoma-associated antigen-expressing cells are cells, primarily found within uterine fibroids (leiomyomas), that exhibit a distinct antigenic profile compared to normal myometrial cells. These cells, including subpopulations of smooth muscle cells (SMCs), vascular SMCs (VSMCs), and fibroblasts, differentially express various proteins like CRABP2, PRB, TGFBR2, and proliferation markers such as Ki-67 and MCM proteins. Furthermore, the presence of myoma-associated antigen-expressing cells is correlated with altered immune profiles in patients. While these antigens may represent potential therapeutic targets or diagnostic biomarkers, careful consideration must be given to specificity to avoid off-target effects.
- Other names
- Uterine fibroid cellLeiomyoma cellMyoma cell
02
Mechanism of action
N/A
03
Biological functions
Cell proliferationExtracellular matrix remodelingResponse to hormonesImmune modulation
04
Disease associations
Uterine fibroids (Leiomyomas)
05
Safety considerations
Potential for off-target effects when targeting antigens expressed in other tissues.
06
Biomarkers
CRABP2 expressionPRB expressionTGFBR2 expressionKi67 expressionMCM3 expressionMCM5 expressionMCM7 expressionNaïve CD4+ T-cells (CD4+CCR7+CD45RA+)Central memory CD4+ T-cellsCD127^high EMRA CD8+ T-cells
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