Myomesin-1 (MYOM1)

Myomesin-1 (MYOM1) is a large, structural protein encoded by the MYOM1 gene that forms an essential component of the M-band in striated muscle sarcomeres[1][3][5]. It cross-links adjacent myosin filaments and connects titin molecules, thereby maintaining the spatial organization and mechanical integrity of the sarcomere during contraction and relaxation. MYOM1 contains fibronectin type III and immunoglobulin-like domains, allowing dimerization and elasticity[1][2][6]. It is involved in mechano-signaling, energy homeostasis, and is critical for proper sarcomere assembly and muscle function[2][5]. Alternative splicing yields tissue- and disease-specific isoforms such as EH-myomesin, which are implicated in the adaptive response to cardiac stress and early stages of dilated cardiomyopathy[1][2][3]. MYOM1 is not known to be a therapeutic target or druggable protein, but its altered expression or splicing is associated with muscular and cardiac diseases, making it an emerging biomarker for muscle damage and disease progression[4][5].

Other names

Myomesin 1190 kDa connectin-associated protein190 kDa titin-associated proteinMyomesin family member 1SkeleminSKELEMINEH-myomesinMyomesin (M-protein) 1 (190kD)Myomesin 1 (skelemin) 185kDaMyomesin 1, 185kDa