Myomesin-2 (MYOM2)

Myomesin-2 (MYOM2) is a large structural protein predominantly expressed in adult cardiac and fast skeletal muscle, where it localizes at the M-band of sarcomeres and provides mechanical stability essential for contraction[1][2][3][5]. It plays a key role in cross-linking thick filaments by binding to myosin, titin, and other sarcomeric proteins, forming part of the cytoskeletal scaffold that ensures the structural and metabolic integrity of muscle fibers[1][5]. MYOM2 also interacts in an isoform-specific manner with muscle-type creatine kinase, which is crucial for localized ATP generation required during muscle contraction[1]. Alterations in MYOM2 expression or structure have been implicated in various muscle and cardiovascular diseases, though it is not a conventional therapeutic target such as a receptor or enzyme[2][3][5]. Its encoded protein consists of multiple immunoglobulin-like and fibronectin type III domains. MYOM2 is essential for normal muscle function but is primarily characterized as a structural, rather than a druggable or therapeutic, molecular target.

Other names

165 kDa connectin-associated protein165 kDa titin-associated proteinM-proteinTTNAPM-band proteinmyomesin family member 2titin-associated protein165 kD