Myomixer (MYMX)

Myomixer (MYMX) is a small, muscle-specific membrane micropeptide essential for the fusion of myoblasts during both embryonic myogenesis and adult skeletal muscle regeneration[1][2][5]. It functions in conjunction with the transmembrane protein Myomaker; both are required for formation and repair of multinucleated muscle fibers[1][2][5]. Myomixer is necessary for satellite cell fusion following muscle injury, and loss of its function leads to a complete block in myofiber regeneration and severe muscle degeneration[1]. Structurally, Myomixer is a membrane-associated peptide with functionally important hydrophobic domains, and it plays a direct role in membrane coalescence and fusion pore formation, analogous to some viral fusogenic peptides[1][2]. Myomixer is not classified as a traditional therapeutic target such as a receptor, enzyme, or transporter, but understanding its function may be relevant for disorders of muscle formation and repair. Currently, there are no drugs or clinical biomarkers directly targeting Myomixer, but it is crucial in developmental and regenerative biology of skeletal muscle[1][2][5].

Other names

Protein myomixerMyoblast fusion factorProtein minionhMINIONMINIONMicroprotein inducer of fusionMyomergerCFZS2protein minionmyomergerprotein myomixermicroprotein inducer of fusion