Target intelligence / Profile preview

Myosin-binding protein C (MyBP-C)

Target: MyBP-C
Molecular classification: Thick filament-associated sarcomeric protein, Intracellular immunoglobulin superfamily

Overview

Myosin-binding protein C (MyBP-C) is a thick filament-associated protein found in striated muscle sarcomeres. It plays a crucial role in thick filament structure and organization, as well as regulation of muscle contraction. The cardiac isoform (cMyBP-C), encoded by the MYBPC3 gene, is expressed exclusively in heart muscle. Mutations in MYBPC3 are a common cause of hypertrophic cardiomyopathy.

Other names: cMyBP-CMYBPC3 (cardiac isoform)MYBPC1 (slow skeletal isoform)MYBPC2 (fast skeletal isoform)

Mechanism of action

Phosphorylation by cAMP-dependent kinase relieves inhibition on crossbridge cycling, enhancing contractility

Biological functions

Structural support of sarcomereRegulation of muscle contractionModulation of actomyosin ATPase activityThick filament organization

Disease associations

Hypertrophic cardiomyopathy

Safety considerations

Mutations can disrupt normal function leading to disease phenotypes through altered structural integrity or regulatory mechanisms within sarcomeres

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