Myosin-binding protein C, fast-type (MYBPC2)

Myosin-binding protein C, fast-type (MYBPC2) is an accessory component of the thick filament in vertebrate striated muscle, specifically enriched in fast skeletal muscle. It is part of the myosin-binding protein C family, which comprises fast-, slow-, and cardiac-type isoforms, each encoded by separate genes. MYBPC2 localizes to the cross-bridge-bearing C region of the A-band and is fundamental for proper sarcomeric architecture, modulating the speed, force, and calcium sensitivity of muscle contraction. The protein engages in specific protein-protein interactions through conserved modular domains, binding both myosin (particularly subfragment 2) and actin, and thereby subtends both structural and regulatory roles within the sarcomere. Genetic mutations in MYBPC2 can result in skeletal myopathies such as distal arthrogryposis, and its absence leads to defective contractile function and compromised muscle regeneration and integrity[2][4][5][6]. Unlike its cardiac and slow skeletal counterparts, MYBPC2 (fast skeletal MyBP-C) is not currently targeted by drugs and is not a known direct therapeutic target.

Other names

MYBPCFFast MyBP-CfsMyBP-CC-protein (skeletal muscle fast isoform)fast skeletal-type muscle myosin-binding protein-Cfast-type muscle myosin-binding-protein Cmyosin binding protein C, fast typetesticular tissue protein Li 126MGC163408